Guest: Stephen Kopecky, M.D.
Host: Sharonne Hayes, M.D.
Statins are very useful to decrease LDL ldl cholesterol and subsequently decrease cardiovascular danger. Studies of statins have excluded topics which can be statin illiberal which is often attributable to muscle signs resembling aches, referred to as myalgias, muscle cramps, or weak spot. One of essentially the most important predictors of statin intolerance is the dose -the greater the dose, the extra prone to develop intolerance. Accepted in really helpful methods to attenuate intolerance is to make use of generic mixture remedy with a decrease dose statin and a ldl cholesterol absorption inhibiting agent resembling ezetimibe. Newer brokers resembling PCS Okay 9 inhibitors and inclisiran, each given subQ, and bempedoic acid might scale back statin muscle signs.
Topics Discussed:
• Is any statin kind of prone to trigger statin related muscle signs?
• Are there any protecting medicines that may decrease statin myalgias?
• What newer non-statin brokers have been proven to scale back danger of myalgias?
• How is treating excessive levels of cholesterol turning into extra like treating blood strain?
0:00 Opening remarks and introduction
3:05 Unexpected findings in research outcomes
6:03 Side results from antihypertensive medicines
9:02 Managing drug doses and affected person communication
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