Special because of Goldman Philanthropic Partnerships for funding this sequence.
Introduction to CLL and Watch and Wait
Dr. Parikh introduces himself and defines Chronic Lymphocytic Leukemia (CLL) as a slow-growing illness that always begins with a watch-and-wait interval.
Criteria for Starting Treatment
Triggers for remedy, together with fatigue, evening sweat, weight modifications, anemia, low platelet counts (underneath 100), and symptomatic enlargement of lymph nodes or the spleen.
Importance of a CLL Specialist
Why being evaluated by a sub-specialist is necessary for navigating fashionable, sub-specialty pushed care.
Patient Evaluation (Comorbidities & Lifestyle)
Non-cancer components like age, comorbidities, medicines, and each day life-style (work/journey) affect the selection of medicine.
Genetic and Genomic Testing
Role of testing for markers like IGHV, FISH, and TP53, which assist predict how lengthy a selected remedy will work.
The Multi-Disciplinary Team
Importance of assembly with pharmacists and nurses to know medicine unintended effects and administration.
Targeted Therapies vs. Chemotherapy
Chemotherapy is never used now, changed by BTK inhibitors, BCL-2 inhibitors, and immunotherapy.
Treatment Combinations and Durations
Compares fixed-duration remedy with steady remedy (ongoing).
Monitoring Response and Relapse
Using a response evaluation to examine for residual illness and that many efficient choices exist if the illness returns.
Clinical Trials, Acknowledgments, & Conclusion
Clinical trial enrollment to enhance requirements of care and a thanks to the sufferers, the Mayo Clinic group, and the Goldman Philanthropic Partnerships for his or her help in creating the video sequence.
00:00 – Introduction to CLL and Watch and Wait
00:50 – Criteria for Starting Treatment
02:53 – Importance of a CLL Specialist
03:03 – Patient Evaluation (Comorbidities & Lifestyle)
04:00 – Genetic and Genomic Testing
05:41 – The Multi-Disciplinary Team
06:03 – Targeted Therapies vs. Chemotherapy
07:03 – Treatment Combinations and Durations
08:24 – Monitoring Response and Relapse
09:10 – Clinical Trials, Acknowledgments, & Conclusion
From Mayo Clinic to your inbox, sign-up at no cost: https://mayocl.in/3e71zfi
Visit Mayo Clinic: https://mayocl.in/2COVmlm
Like Mayo Clinic on Facebook: https://www.facebook.com/mayoclinic/
Follow Mayo Clinic on Instagram: https://www.instagram.com/mayoclinic/
Follow Mayo Clinic on X, previously Twitter: https://x.com/MayoClinic
Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic
