In this analysis, Ieng Lam Lei, Ph.D., identifies the epigenetic regulator Brd4-S as a key driver of preservation harm, displaying that it promotes irritation and cell loss of life throughout chilly storage, and that silencing it improves coronary heart perform. By concentrating on Brd4-S with particular inhibitors and testing this strategy in preclinical fashions, the examine goals to enhance donor coronary heart preservation, develop the donor pool, and improve transplant outcomes.
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