Idiopathic hypersomnia is typically considered the stepchild of narcolepsy. But it might be extra frequent than its higher identified relation. In this podcast, we mentioned the prognosis and administration of this elusive dysfunction.
0:00 – Welcome to Mayo Clinic Sleep Medicine Podcast
0:39 – What is idiopathic hypersomnia?
1:12 – Guest introduction: Dr. Maggie Blattner
1:27 – Is idiopathic hypersomnia a prognosis of exclusion?
1:49 – Heterogeneity and scientific phenotypes of IH
3:19 – Diagnostic standards and ICSD‑3 overview
4:53 – Sensitivity and reliability of MSLT in IH
6:29 – Long sleep period instead diagnostic criterion
7:44 – Role of actigraphy vs. 24‑hour sleep research
9:35 – Practical challenges of extended sleep testing
11:28 – Classic IH phenotype with lengthy sleep
12:26 – Hypotheses about underlying mechanisms of IH
13:02 – Sleep drive, GABA signaling, and irritation
14:05 – Circadian rhythm involvement
15:26 – Differentiating IH from continual fatigue syndrome
16:59 – Stimulants and wake‑selling medicines
18:33 – Low‑sodium oxybate for idiopathic hypersomnia
20:54 – Clarithromycin: proof and issues
24:44 – Need for managed trials
25:04 – Closing remarks
25:47 – Podcast wrap‑up and signal‑off
From Mayo Clinic to your inbox, sign-up at no cost: https://mayocl.in/3e71zfi
Visit Mayo Clinic: https://mayocl.in/2COVmlm
Like Mayo Clinic on Facebook: https://www.facebook.com/mayoclinic/
Follow Mayo Clinic on Instagram: https://www.instagram.com/mayoclinic/
Follow Mayo Clinic on X, previously Twitter: https://x.com/MayoClinic
Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic
