Guest: John Giudicessi, M.D., Ph.D.
Host: Malcolm Bell, M.D.
In this podcast, listeners will study what gene remedy is and the varieties of genes therapies beneath improvement for an array of genetically mediated cardiovascular issues. In addition, energetic and upcoming gene remedy scientific trials for the therapy of particular arrhythmogenic, dilated, hypertrophic and restrictive cardiomyopathy genotypes can be mentioned.
Topics Discussed:
• What is gene remedy?
• How do gene therapies differ from typical administration of genetic arrhythmogenic, dilated, hypertrophic and restrictive cardiomyopathies?
• Are there several types of gene therapies?
• What gene remedy trials are presently energetic or upcoming at Mayo Clinic and different establishments?
00:00 Gene remedy focus and key visitor
00:58 What gene remedy is
01:44 Gene remedy vs cell remedy
02:18 Which genetic coronary heart ailments matter
03:13 How gene remedy is delivered
04:22 Using AAV vectors and coronary heart concentrating on
06:55 How therapy is run (IV)
07:24 How a lot of the guts is handled
08:24 Phase 1 trials: dosing and security
08:53 HCM instance and “critical mass”
10:15 One-and-done or future “top-offs”
11:55 Key dangers and antagonistic results
13:47 Other approaches, together with gene enhancing
14:59 Trials to observe and referrals
16:55 Why genetic testing is crucial
17:31 Wrap-up and future outlook
18:45 Mayo Clinic CV training sources
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