Special because of Goldman Philanthropic Partnerships for funding this sequence.
00:00 – Introduction to Hodgkin’s Lymphoma
00:28 – Common Symptoms and Diagnosis
01:12 – Staging the Disease
02:02 – Treatment Based on Stage
02:40 – Traditional Chemotherapy (ABVD)
03:24 – Novel Therapies and Targeted Agents
04:13 – BV-AVD Combination
05:11 – Nivolumab and AVD
05:52 – Summary and Future Outlook
06:20 – Conclusion and Acknowledgments
Descriptions:
00:00 – Introduction to Hodgkin’s Lymphoma
Introduction to Dr. Urshila Durani as a lymphoma specialist at Mayo Clinic and a quick overview of Hodgkin’s lymphoma.
00:28 – Common Symptoms and Diagnosis
Typical signs of Hodgkin’s lymphoma, resembling enlarged lymph nodes, intense itchiness, and night time sweats. Definitive analysis usually requires a core needle biopsy or an excisional biopsy.
01:12 – Staging the Disease
Importance of staging to grasp the extent of the illness. A PET-CT scan is highlighted as the most effective instrument for this, serving to to find out if the illness is in its early phases (Stage 1 or 2) or extra superior (Stage 3 or 4).
02:02 – Treatment Based on Stage
How the stage of the illness straight influences the remedy plan. Early-stage illness is commonly handled with a mixture of chemotherapy and radiation, whereas advanced-stage illness is often managed with chemotherapy alone.
02:40 – Traditional Chemotherapy (ABVD)
Traditional four-drug routine referred to as ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine), which has been an ordinary remedy for many years. Potential for long-term toxicities, resembling coronary heart illness and different cancers.
03:24 – Novel Therapies and Targeted Agents
New, revolutionary remedy approaches that intention to scale back the long-term negative effects of conventional chemotherapy whereas sustaining excessive remedy charges.
04:13 – BV-AVD Combination
BV-AVD routine, which mixes chemotherapy with a brand new drug referred to as brentuximab vedotin (BV). BV is a focused chemotherapy that particularly assaults lymphoma cells, and this mixture has been proven to enhance survival charges.
05:11 – Nivolumab and AVD
Even newer routine that pairs chemotherapy with the immunotherapy drug nivolumab. This remedy "wakes up" the immune system to struggle the most cancers and exhibits promising outcomes with doubtlessly fewer negative effects.
05:52 – Summary and Future Outlook
Summary of the progress in treating Hodgkin’s lymphoma, from radiation alone to trendy, focused therapies.
06:20 – Conclusion and Acknowledgments
The video concludes with a thanks to the sufferers, the Mayo Clinic group, and the Goldman Philanthropic Partnerships for his or her beneficiant reward that made the video sequence potential.
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