Special due to Goldman Philanthropic Partnerships for funding this sequence.
00:00 – Introduction to CAR-T Therapy
00:39 – FDA-Approved Indications
01:54 – How CAR-T Cells are Made
03:07 – The Treatment Process and Side Effects
04:30 – The Efficacy of CAR-T Therapy
05:17 – The Patient Journey and Logistics
08:21 – Unprecedented Clinical Response
08:52 – Conclusion and Acknowledgments
Descriptions:
00:00 – Introduction to CAR-T Therapy
Introduction to Dr. Yi Lin, Medical Director of the Mayo Clinic’s cell remedy program and CAR-T (chimeric antigen receptor T-cell) remedy as a transformative immunotherapy for lymphoma sufferers.
00:39 – FDA-Approved Indications
Various sorts of lymphoma for which CAR-T remedy is FDA-approved. These embrace aggressive non-Hodgkin lymphomas like diffuse giant B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL), in addition to indolent lymphomas equivalent to follicular lymphoma (FL).
01:54 – How CAR-T Cells are Made
CAR-T cells are created from a affected person’s personal T-cells, making it a extremely personalised therapy. The affected person’s white blood cells are collected and despatched to a lab, the place they’re genetically modified to develop into CAR-T cells.
03:07 – The Treatment Process and Side Effects
Before the CAR-T cells are infused, sufferers obtain chemotherapy to organize their immune system. This permits the brand new CAR-T cells to multiply and develop into energetic. Unique unwanted effects can happen, equivalent to cytokine launch syndrome and neurologic adjustments, that are carefully monitored by specialists on the therapy heart for a couple of month after infusion.
04:30 – The Efficacy of CAR-T Therapy
Emphasis on the unprecedented scientific response charges and the potential for a long-lasting, sturdy remission, and even a remedy for a lot of sufferers.
05:17 – The Patient Journey and Logistics
Outlines of the standard affected person journey. It begins with a referral to a specialised CAR-T therapy heart for analysis. Patients then bear a process referred to as leukapheresis to gather their white blood cells. After the CAR-T cells are manufactured, the affected person returns for the infusion.
08:21 – Unprecedented Clinical Response
The important impression of CAR-T remedy, skill to supply sturdy remission and a remedy for a lot of sufferers with relapsed refractory lymphoma.
08:52 – Conclusion and Acknowledgments
The video concludes with a thanks to the sufferers, the Mayo Clinic group, and the Goldman Philanthropic Partnerships for his or her beneficiant help in creating this academic sequence.
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