Special because of Goldman Philanthropic Partnerships for funding this collection.
Introduction to Mantle Cell Lymphoma (MCL)
Dr. Wang defines MCL as an unusual B-cell non-Hodgkin lymphoma that’s "heterogeneous," which means it presents in another way in each affected person.
The Importance of Accurate Diagnosis
Confirming the analysis by means of specialised pathology or repeat biopsy is essential to distinguish MCL from different lymphoma subtypes.
High-Risk Features & Biomarkers
Biomarkers just like the TP53 mutation, Ki-67 proliferation index, and blastoid variants that assist tailor a particular remedy plan.
Is Immediate Treatment Necessary?
Some slow-growing circumstances permit for statement, whereas aggressive circumstances require quick intervention.
The "Watch and Wait" Strategy
Safety of observing sufferers who’re asymptomatic and have steady blood counts.
Intensive Therapy & Stem Cell Transplant
High-intensity regimens for youthful sufferers, adopted by autologous stem cell transplants.
Milder Treatment Approaches
Options for older sufferers, milder regimens reminiscent of bendamustine rituximab (BR), adopted by upkeep remedy.
Recent Advances & BTK Inhibitors
New oral "pill form" medicines are altering the sphere, typically permitting sufferers to keep away from intensive transplants or high-dose chemo.
Future Outlook: Bispecific Antibodies & CAR T-cell
The transfer towards "chemo-free" therapies utilizing bispecific antibodies and CAR-T cell remedy in frontline care.
Acknowledgments & Conclusion
A thanks to the sufferers, the Mayo Clinic workforce, and the Goldman Philanthropic Partnerships for his or her help in creating the video collection.
00:00 – Introduction to Mantle Cell Lymphoma (MCL)
00:44 – The Importance of Accurate Diagnosis
01:37 – High-Risk Features & Biomarkers
02:28 – Is Immediate Treatment Necessary?
03:07 – The "Watch and Wait" Strategy
03:49 – Milder Treatment Approaches
04:36 – Treatment Options for Older/Less-Fit Patients
05:05 – Recent Advances & BTK Inhibitors
06:49 – Future Outlook: Bispecific Antibodies & CAR T-cell
07:07 – Acknowledgments & Conclusion
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